分子量：Calculated MW: 75kDa
Observed MW: 76kDa

细胞定位：Cell projection, podosome

稀释方法：WB 1:500 - 1:2000
IF 1:50 - 1:200

总结：Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms.