PAK2 polyclonal antibody
产品名称： PAK2 polyclonal antibody
英文名称： PAK2 polyclonal antibody
产品编号： PAB2299
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PAK2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PAK2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.
Martin GA, Bollag G, McCormick F, Abo A.EMBO J. 1995 Sep 1;14(17):4385.
- 2.
- Activation of an S6/H4 kinase (PAK 65) from human placenta by intramolecular and intermolecular autophosphorylation.
Benner GE, Dennis PB, Masaracchia RA.J Biol Chem. 1995 Sep 8;270(36):21121-8.
- 3.
- A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.
Martin GA, Bollag G, McCormick F, Abo A.EMBO J. 1995 May 1;14(9):1970-8.
- Applications
- Western Blot (Cell lysate)
- The PAK2 polyclonal antibody (Cat # PAB2299) is used in Western blot to detect PAK2 in ovary cell lysate. Data is kindly provided by Elena Black from Boston University (Boston, MA) .
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with the PAK2 polyclonal antibody (Cat # PAB2299) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 5062
- Protein Accession#:
- Q13177
- Gene Name:
- PAK2
- Gene Alias:
- PAK65,PAKgamma
- Gene Description:
- p21 protein (Cdc42/Rac)-activated kinase 2
- Omim ID:
- 605022
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq
- Other Designations:
- S6/H4 kinase,p21 (CDKN1A)-activated kinase 2,p21-activated kinase 2
- Related Disease